|本期目录/Table of Contents|

[1]尹桂波,Victor Leung,Frank.K.Ko,等.含有取向纳米纤维束的神经移植物构建与神经修复应用研究[J].现代纺织技术,2017,25(06):1-6.
 YIN Guibo,VICTOR Leung,FRANK.K.Ko,et al.Construction of a Novel Nerve Regeneration Graft with NanofibersBundles and Its Application in Neural Tissue Engineering[J].Advanced Textile Technology,2017,25(06):1-6.
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含有取向纳米纤维束的神经移植物构建与神经修复应用研究()
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《现代纺织技术》[ISSN:1009-265X/CN:33-1249/TS]

卷:
25
期数:
2017年06期
页码:
1-6
栏目:
出版日期:
2019-11-05

文章信息/Info

Title:
Construction of a Novel Nerve Regeneration Graft with NanofibersBundles and Its Application in Neural Tissue Engineering
文章编号:
1009-265X(2017)06-0001-06
作者:
尹桂波Victor LeungFrank.K.KoWolfram Tetzlaff刘婕
1.江苏工程职业技术学院纺染工程学院,江苏南通226007;2.卑诗哥伦比亚大学材料工程系先进纤维材料实验室,温哥华,V6T 1Z4,加拿大;3.卑诗哥伦比亚大学医学院动物与外科学系,温哥华,V5Z 1M9,加拿大
Author(s):
YIN Guibo VICTOR Leung FRANK.K.Ko WOLFRAM Tetzlaff LIU Jie
1.School of Textile and Dying Engineering, Jiangsu College of Engineering and Technology, Nantong226007, China; 2.Advanced Fibrous Materials Laboratory, Department of material engineering,University of British Columbia, Vancouver, V6T 1Z4, Canada; 3.Department of Zoologyand Surgery, University of British Columbia, Vancouver, V5Z 1M9, Canada
关键词:
聚乳酸纳米纤维静电纺丝神经修复生物性能
分类号:
TB383
文献标志码:
A
摘要:
为提高纳米纤维神经移植物的接触引导,设计了一种含有取向纳米纤维束的“芯鞘”型神经移植物,它利用静电纺高取向纳米纤维膜,两次卷绕形成“芯”和“鞘”,最后通过静电纺丝喷覆而成。利用扫描电镜观察并表征了纤维及其移植物形态,测试了力学性能,将此移植物用于大鼠10 mm坐骨神经缺损,术后两月通过体外刺激和组织学观察了修复效果。结果表明:通过调整静电纺收集转辊转速可获得高取向聚乳酸纳米纤维,纳米纤维膜工程应力和伸长率达到(49.32±14.83) MPa和17.71%±0.06%,利用该膜构建的神经移植物缝合强力达到(1.18±0.40) N/针,能支持与保护神经再生,移植两月后,大鼠能够感知热与外力刺激,组织学观察发现,有神经纤维和血旺细胞长入神经移植物,证明了该构建技术的可行性,并有可能为神经修复提供一种新的移植材料。

参考文献/References:

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[7] BIAN Y Z, WANG Y, AIBAIDOULA G, et al. Evaluation of poly(3hydroxybutyrateco3hydroxyhexanoate) conduits for peripheral nerve regeneration[J]. Biomaterials, 2008,30(2):217-225.
[8] KIM Y T, HAFTEL V K, KUMER S, et al. The role of aligned polymer fiberbased constructs in the bridging of long peripheral nerve gaps[J]. Biomaterials, 2008,29(21):3117-3127.
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备注/Memo

备注/Memo:
收稿日期:2017-02-17
网络出版日期:2017-05-31
基金项目:江苏高校品牌专业建设工程(PPZY2015A093);江苏省先进纺织工程技术中心项目(苏政办发2014[22]号);江苏高校优秀中青年教师境外研修项目(苏教师[2012]6号);南通市新型纤维材料重点实验室项目资助(CP12014003)
作者简介:尹桂波(1978-),男,山东诸诚人,副教授,博士,主要从事纳米纤维及生物医用材料方面的研究
更新日期/Last Update: 2017-11-14